Anti Jo-1 Antibody
Sample: Serum
Schedule: Daily
Units:
Range: Negative
Remarks: Antibodies to the autoantigen Jo-1 (histidyl-RNA synthetase) are found in a subgroup of connective tissue disease patients with pure polymyositis, pure dermatomyositis, or myositis associated with another rheumatic disease. Antibodies to Jo-1 are found in 18-36% of all patients satisfying the criteria for myositis.
The antibody is more common in polymyositis than dermatomyositis and rarely found in other disease states. Antibodies to Jo-1 are strongly associated with interstitial lung disease, with nearly all Jo-1 positive patients showing evidence of lung involvement. A relationship of Jo-1 antibody titer and disease activity has been reported, but to date this has not been confirmed. Jo-1 antibody are also ssessed with ENA (Extractable Nuclear Antibody) screening test.
