Anti Glomerular Basement Membrane
Sample: Serum
Schedule: Daily (Immunofluorescence)
Units: Titer
Range: Negative
Remarks: The anti-glomerular basement membrane (anti-GBM) is an antibody directed to the GBM and alveolar basement membrane. The resultant clinical syndrome (Goodpasture syndrome) includes from mild or no renal involvement to rapidly progressive glomerulonephritis.
Patients may develop pulmonary hemorrhage, and most individuals have signs of a generalized systemic illness. Because similar symptoms can be seen in other conditions, such as ANCA-C/ANCA-P vasculitis and other autoimmune disorders, the identification of anti-GBM antibodies is of critical importance in the diagnosis of Goodpasture disease.
